The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

@article{Lynch2018TheRP,
  title={The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity},
  author={C. Lynch and R. Bernad and Isabel A. Calvo and Sandrina N{\'o}brega-Pereira and S. Ru{\'i}z and Nuria Ibarz and Ana Mart{\'i}nez-Val and O. Gra{\~n}a-Castro and G. G{\'o}mez-L{\'o}pez and E. Andr{\'e}s-Le{\'o}n and Vladimir Espinosa Angarica and A. del Sol and S. Ortega and {\'O}. Fern{\'a}ndez-Capetillo and E. Rojo and J. Mu{\~n}oz and M. Serrano},
  journal={Cell Reports},
  year={2018},
  volume={22},
  pages={396 - 410}
}
  • C. Lynch, R. Bernad, +14 authors M. Serrano
  • Published 2018
  • Medicine, Biology
  • Cell Reports
  • Summary The RNA polymerase II-associated protein 1 (RPAP1) is conserved across metazoa and required for stem cell differentiation in plants; however, very little is known about its mechanism of action or its role in mammalian cells. Here, we report that RPAP1 is essential for the expression of cell identity genes and for cell viability. Depletion of RPAP1 triggers cell de-differentiation, facilitates reprogramming toward pluripotency, and impairs differentiation. Mechanistically, we show that… CONTINUE READING

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