The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

@article{Lynch2018TheRP,
  title={The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity},
  author={Cian J. Lynch and Raquel Bernad and Isabel Calvo and Sandrina N{\'o}brega-Pereira and Sergio Ruiz and Nuria Ibarz and Ana Mart{\'i}nez-Val and Osvaldo Gra{\~n}a-Castro and Gonzalo G{\'o}mez-L{\'o}pez and Eduardo Andr{\'e}s-Le{\'o}n and Vladimir Espinosa Angarica and Antonio del Sol and Sagrario Ortega and Oscar Fernandez-Capetillo and Enrique Rojo and Javier Mu{\~n}oz and Manuel Serrano},
  journal={Cell Reports},
  year={2018},
  volume={22},
  pages={396 - 410}
}
Summary The RNA polymerase II-associated protein 1 (RPAP1) is conserved across metazoa and required for stem cell differentiation in plants; however, very little is known about its mechanism of action or its role in mammalian cells. Here, we report that RPAP1 is essential for the expression of cell identity genes and for cell viability. Depletion of RPAP1 triggers cell de-differentiation, facilitates reprogramming toward pluripotency, and impairs differentiation. Mechanistically, we show that… Expand
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