The RNA Methyltransferase Misu (NSun2) Mediates Myc-Induced Proliferation and Is Upregulated in Tumors

Abstract

BACKGROUND Myc is a well-known proto-oncogene, but its functions in normal tissue remain enigmatic. In adult epidermis, Myc stimulates exit from the stem cell compartment, decreasing cell adhesion and, by an unknown mechanism, triggering proliferation of transit-amplifying cells. RESULTS We describe a novel direct target gene of Myc, Misu, that is… (More)
DOI: 10.1016/j.cub.2007.11.006

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