The RNA Chaperone Hfq Is Essential for Virulence and Modulates the Expression of Four Adhesins in Yersinia enterocolitica

@inproceedings{Kakoschke2016TheRC,
  title={The RNA Chaperone Hfq Is Essential for Virulence and Modulates the Expression of Four Adhesins in Yersinia enterocolitica},
  author={Tamara Katharina Kakoschke and Sara Carina Kakoschke and Catharina Zeuzem and Hicham Bouabe and Kristin Adler and Juergen Heesemann and Ombeline Rossier},
  booktitle={Scientific reports},
  year={2016}
}
In Enterobacteriaceae, the RNA chaperone Hfq mediates the interaction of small RNAs with target mRNAs, thereby modulating transcript stability and translation. This post-transcriptional control helps bacteria adapt quickly to changing environmental conditions. Our previous mutational analysis showed that Hfq is involved in metabolism and stress survival in the enteropathogen Yersinia enterocolitica. In this study we demonstrate that Hfq is essential for virulence in mice and influences… CONTINUE READING
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