The RNA Binding Protein TLS Is Translocated to Dendritic Spines by mGluR5 Activation and Regulates Spine Morphology

@article{Fujii2005TheRB,
  title={The RNA Binding Protein TLS Is Translocated to Dendritic Spines by mGluR5 Activation and Regulates Spine Morphology},
  author={Ritsuko Fujii and Shigeo Okabe and Tomoe Urushido and Kiyoshi Inoue and Atsushi Yoshimura and Taro Tachibana and Toru Nishikawa and Geoffrey G. Hicks and Toru Takumi},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={587-593}
}
Neuronal dendrites, together with dendritic spines, exhibit enormously diverse structure. Selective targeting and local translation of mRNAs in dendritic spines have been implicated in synapse remodeling or synaptic plasticity. The mechanism of mRNA transport to the postsynaptic site is a fundamental question in local dendritic translation. TLS (translocated in liposarcoma), previously identified as a component of hnRNP complexes, unexpectedly showed somatodendritic localization in mature… CONTINUE READING
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