The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting.

@article{Santangelo2016TheRP,
  title={The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting.},
  author={Laura Santangelo and Giorgio Giurato and Carla Cicchini and Claudia Montaldo and Carmine Mancone and Roberta Tarallo and Cecilia Battistelli and Tonino Alonzi and Alessandro Weisz and Marco Tripodi},
  journal={Cell reports},
  year={2016},
  volume={17 3},
  pages={799-808}
}
Despite clear evidence that exosomal microRNAs (miRNAs) are able to modulate the cellular microenvironment and that exosomal RNA cargo selection is deregulated in pathological conditions, the mechanisms controlling specific RNA sorting into extracellular vesicles are still poorly understood. Here, we identified the RNA binding protein SYNCRIP (synaptotagmin-binding cytoplasmic RNA-interacting protein; also known as hnRNP-Q or NSAP1) as a component of the hepatocyte exosomal miRNA sorting… CONTINUE READING
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