The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing

  title={The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing},
  author={Feng-Yang Zong and Xing Fu and Wen-Juan Wei and Ya-Ge Luo and Monika Heiner and Lijuan Cao and Zhaoyuan Fang and Rong Fang and Daru Lu and Hongbin Ji and Jingyi Hui},
  booktitle={PLoS genetics},
Lung cancer is the leading cause of cancer-related death worldwide. Aberrant splicing has been implicated in lung tumorigenesis. However, the functional links between splicing regulation and lung cancer are not well understood. Here we identify the RNA-binding protein QKI as a key regulator of alternative splicing in lung cancer. We show that QKI is frequently down-regulated in lung cancer, and its down-regulation is significantly associated with a poorer prognosis. QKI-5 inhibits the… CONTINUE READING
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