The RNA-Binding Protein KSRP Promotes Decay of β-Catenin mRNA and Is Inactivated by PI3K-AKT Signaling

@article{Gherzi2006TheRP,
  title={The RNA-Binding Protein KSRP Promotes Decay of β-Catenin mRNA and Is Inactivated by PI3K-AKT Signaling},
  author={Roberto Gherzi and Michele Trabucchi and Marco Ponassi and Tina Ruggiero and Giorgio Corte and Christoph Moroni and C F Chen and Khalid S. A. Khabar and Jens Skorstensgaard Andersen and Paola Briata},
  journal={PLoS Biology},
  year={2006},
  volume={5},
  pages={491 - 497}
}
Beta-catenin plays an essential role in several biological events including cell fate determination, cell proliferation, and transformation. Here we report that beta-catenin is encoded by a labile transcript whose half-life is prolonged by Wnt and phosphatidylinositol 3-kinase-AKT signaling. AKT phosphorylates the mRNA decay-promoting factor KSRP at a unique serine residue, induces its association with the multifunctional protein 14-3-3, and prevents KSRP interaction with the exoribonucleolytic… CONTINUE READING

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