The RIP kinases: crucial integrators of cellular stress.

  title={The RIP kinases: crucial integrators of cellular stress.},
  author={Etienne Meylan and J. -M. Tschopp},
  journal={Trends in biochemical sciences},
  volume={30 3},
Since the discovery of the first member ten years ago, the receptor-interacting protein (RIP) family kinases have emerged as essential sensors of cellular stress. The different members integrate both extracellular stress signals transmitted by various cell-surface receptors and signals emanating from intracellular stress. The cascades of events initiated by activated RIPs are complex. Not only are pro-survival, inflammatory and immune responses triggered by RIP kinases via the activation of… CONTINUE READING