The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells.

@article{ShojiKawata2007TheRF,
  title={The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells.},
  author={Sanae Shoji-Kawata and Qiu Zhong and Masanori Kameoka and Yukie Iwabu and Sompong Sapsutthipas and Ronald B. Luftig and Kazuyoshi Ikuta},
  journal={Virology},
  year={2007},
  volume={368 1},
  pages={191-204}
}
CXCR4-using HIV-1 was previously shown to replicate more efficiently in a healthy donor-derived CD4(+) CD38(+) than in a CD4(+) CD38(-) T-cell subset after stimulation with interleukin (IL)-4. Here, we identified 3 cellular genes, which were expressed to a higher level in an IL-4-stimulated CD38(-) subset. One of the 3 genes, RNF125/TRAC-1, was involved in the down-regulation of HIV-1 replication not only in cell lines, but also in peripheral blood mononuclear cells. RNF125/TRAC-1 bears the… CONTINUE READING

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