The RIIbeta regulatory subunit of protein kinase A binds to cAMP response element: an alternative cAMP signaling pathway.

@article{Srivastava1998TheRR,
  title={The RIIbeta regulatory subunit of protein kinase A binds to cAMP response element: an alternative cAMP signaling pathway.},
  author={Rakesh K Srivastava and Young Nam Lee and Kohji Noguchi and Yun Gyu Park and Matthew N Bainbridge and Jae Seok Jeong and Se Nyun Kim and Y S Cho-chung},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 12},
  pages={6687-92}
}
cAMP, through the activation of cAMP-dependent protein kinase (PKA), is involved in transcriptional regulation. In eukaryotic cells, cAMP is not considered to alter the binding affinity of CREB/ATF to cAMP-responsive element (CRE) but to induce serine phosphorylation and consequent increase in transcriptional activity. In contrast, in prokaryotic cells, cAMP enhances the DNA binding of the catabolite repressor protein to regulate the transcription of several operons. The structural similarity… CONTINUE READING