The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice.

@article{Singh2014TheRP,
  title={The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice.},
  author={Maneesh Singh and Pratibha Singh and Dolor{\`e}s Vaira and Eirik A Torheim and Souad Rahmouni and Kjetil Task{\'e}n and Michel P. Moutschen},
  journal={European journal of clinical investigation},
  year={2014},
  volume={44 2},
  pages={146-52}
}
BACKGROUND Increased intracellular concentration of cyclic AMP (cAMP) in T cells is associated with various immunodeficiency conditions including human immunodeficiency virus (HIV) infection. Several reports indicate a critical role of activated protein kinase A (PKA) in the susceptibility of cells to HIV infection. We have used a cell permeable, stable peptidomimetic version (P3) of the RI-anchoring disruptor (RIAD), which prevents PKA interaction with A-kinase-anchoring proteins (AKAPs). It… CONTINUE READING

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