The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis.

Abstract

Defects in cellular metabolism have been widely implicated in causing male infertility, but there has been little progress in understanding the underlying mechanism. Here we report that several key metabolism genes are regulated in the testis by Rhox5, the founding member of a large X-linked homeobox gene cluster. Among these Rhox5-regulated genes are… (More)
DOI: 10.1074/jbc.M113.486340

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