The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans.

@article{Tian2010TheRP,
  title={The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans.},
  author={Chenxi Tian and Debjeet Sen and Herong Shi and Marisa L. Foehr and Yevgeniy Plavskin and Olena K. Vatamaniuk and Jun Yong Liu},
  journal={Development},
  year={2010},
  volume={137 14},
  pages={
          2375-84
        }
}
The bone morphogenetic protein (BMP) signaling pathway regulates multiple developmental and homeostatic processes. Mutations in the pathway can cause a variety of somatic and hereditary disorders in humans. Multiple levels of regulation, including extracellular regulation, ensure proper spatiotemporal control of BMP signaling in the right cellular context. We have identified a modulator of the BMP-like Sma/Mab pathway in C. elegans called DRAG-1. DRAG-1 is the sole member of the repulsive… CONTINUE READING

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