The RGD-containing domain of exogenous HIV-1 Tat inhibits the engulfment of apoptotic bodies by dendritic cells.

@article{Zocchi1997TheRD,
  title={The RGD-containing domain of exogenous HIV-1 Tat inhibits the engulfment of apoptotic bodies by dendritic cells.},
  author={Maria Raffaella Zocchi and Alessandro Poggi and Anna Rubartelli},
  journal={AIDS},
  year={1997},
  volume={11 10},
  pages={1227-35}
}
OBJECTIVE HIV-1 Tat can be released by infected cells and exert various extracellular functions on bystander cells, possibly contributing to immunodeficiency. In order to investigate whether exogenous Tat can affect antigen presentation, the effects of synthetic Tat on the function of dendritic cells displaying antigen presenting cell phenotype were studied. DESIGN Cultured dendritic cells were challenged with apoptotic bodies and monitored for cell engulfment and free intracellular calcium… CONTINUE READING