The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis

Abstract

Increasing incidence of inflammatory bowel disorders demands a better understanding of the molecular mechanisms underlying its multifactorial aetiology. Here we demonstrate that mice deficient for REGγ, a proteasome activator, show significantly attenuated intestinal inflammation and colitis-associated cancer in dextran sodium sulfate model. Bone marrow… (More)
DOI: 10.1038/ncomms10761

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