The RCAF complex mediates chromatin assembly during DNA replication and repair

  title={The RCAF complex mediates chromatin assembly during DNA replication and repair},
  author={Jessica K Tyler and Christopher R. Adams and S Chen and Ryuji Kobayashi and Rohinton T. Kamakaka and James T. Kadonaga},
Chromatin assembly is a fundamental biological process that is essential for the replication and maintenance of the eukaryotic genome. In dividing cells, newly synthesized DNA is rapidly assembled into chromatin by the deposition of a tetramer of the histone proteins H3 and H4, followed by the deposition of two dimers of histones H2A and H2B to complete the nucleosome—the fundamental repeating unit of chromatin. Here we describe the identification, purification, cloning, and characterization of… CONTINUE READING
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