The RB1 gene is the target of chromosome 13 deletions in malignant fibrous histiocytoma.

@article{Chibon2000TheRG,
  title={The RB1 gene is the target of chromosome 13 deletions in malignant fibrous histiocytoma.},
  author={Fr{\'e}d{\'e}ric Chibon and Aline Mairal and Paul Fr{\'e}neaux and Philippe Terrier and J. M. Coindre and Xavier Sastre and Alain Aurias},
  journal={Cancer research},
  year={2000},
  volume={60 22},
  pages={6339-45}
}
Forty-four malignant fibrous histiocytomas (MFHs) were studied by comparative genomic hybridization. Among the observed imbalances, losses of the 13q14-q21 region were observed in almost all tumors (78%), suggesting that a gene localized in this region could act as a tumor suppressor gene and that its inactivation could be relevant for MFH oncogenesis and/or progression. We determined by CA repeat analyses a consensus region of deletion focusing on the RB1 region. The RB1 gene was then analyzed… CONTINUE READING
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