The RB and p53 pathways in cancer.

  title={The RB and p53 pathways in cancer.},
  author={Charles J Sherr and Frank Mccormick},
  journal={Cancer cell},
  volume={2 2},
The life history of cancer cells encompasses a series of genetic missteps in which normal cells are progressively transformed into tumor cells that invade surrounding tissues and become malignant. Most prominent among the regulators disrupted in cancer cells are two tumor suppressors, the retinoblastoma protein (RB) and the p53 transcription factor. Here, we discuss interconnecting signaling pathways controlled by RB and p53, attempting to explain their potentially universal involvement in the… CONTINUE READING
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