The RAS/Raf1/MEK/ERK signaling pathway facilitates VSV-mediated oncolysis: implication for the defective interferon response in cancer cells.

@article{Noser2007TheRS,
  title={The RAS/Raf1/MEK/ERK signaling pathway facilitates VSV-mediated oncolysis: implication for the defective interferon response in cancer cells.},
  author={Josh A. Noser and Amber A. Mael and Ryuta Sakuma and Seiga Ohmine and Paola Marcato and Patrick W. K. Lee and Yasuhiro Ikeda},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2007},
  volume={15 8},
  pages={
          1531-6
        }
}
Vesicular stomatitis virus (VSV) can replicate in malignant cells more efficiently than in normal cells. Although the selective replication appears to be caused by defects in the interferon (IFN) system in malignant cells, the mechanisms which render these cells less responsive to IFN remain poorly understood. Here we present evidence that an activated RAS/Raf1/MEK/ERK pathway plays a critical role in the defects. NIH 3T3 or human primary cells stably expressing active RAS or Raf1 were rapidly… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 51 CITATIONS, ESTIMATED 69% COVERAGE

Targeting Melanoma with Cancer-Killing Viruses

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2008
2018

CITATION STATISTICS

  • 3 Highly Influenced Citations

Similar Papers