The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review).

@article{Jimi2013TheRS,
  title={The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review).},
  author={Eijiro Jimi and Masashi Shin and Hiroyuki Furuta and Yukiyo Tada and Jingo Kusukawa},
  journal={International journal of oncology},
  year={2013},
  volume={42 3},
  pages={
          803-9
        }
}
Squamous cell carcinomas (SCCs) of the gingiva frequently invade the mandible or maxilla; this invasion is associated with a worse prognosis. The bone destruction associated with carcinomal invasion is mediated by osteoclasts rather than directly by the carcinoma. Therefore, if the cellular and molecular mechanisms by which oral SCC regulates bone invasion were known, it could inform the development of new therapeutic targets. Recently… CONTINUE READING

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