The RANK–RANKL axis: an opportunity for drug repurposing in cancer?

  title={The RANK–RANKL axis: an opportunity for drug repurposing in cancer?},
  author={S. Peters and Philippe Cl{\'e}zardin and Iv{\'a}n M{\'a}rquez-Rodas and Daniela Niepel and Craig Gedye},
  journal={Clinical and Translational Oncology},
Drug repurposing offers advantages over traditional drug development in terms of cost, speed and improved patient outcomes. The receptor activator of nuclear factor kappa B (RANK) ligand (RANKL) inhibitor denosumab is approved for the prevention of skeletal-related events in patients with advanced malignancies involving bone, including solid tumours and multiple myeloma. Following improved understanding of the role of RANK/RANKL in cancer biology, denosumab has already been repurposed as a… 
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