The RAB family GTPase Rab1A from Plasmodium falciparum defines a unique paralog shared by chromalveolates and rhizaria.

@article{Eli2009TheRF,
  title={The RAB family GTPase Rab1A from Plasmodium falciparum defines a unique paralog shared by chromalveolates and rhizaria.},
  author={Marek Eli{\'a}{\vs} and Nicola J Patron and Patrick J Keeling},
  journal={The Journal of eukaryotic microbiology},
  year={2009},
  volume={56 4},
  pages={348-56}
}
The RAB GTPases, which are involved in regulation of endomembrane trafficking, exhibit a complex but incompletely understood evolutionary history. We elucidated the evolution of the RAB1 subfamily ancestrally implicated in the endoplasmic reticulum-to-Golgi traffic. We found that RAB1 paralogs have been generated over the course of eukaryotic evolution, with some duplications coinciding with the advent of major eukaryotic lineages (e.g. Metazoa, haptophytes). We also identified a unique… CONTINUE READING
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