The R753Q polymorphism abrogates toll-like receptor 2 signaling in response to human cytomegalovirus.


Toll-like receptor 2 (TLR2) serves as a pattern recognition receptor that signals the presence of cytomegalovirus. Herein, we report that R753Q polymorphism paralyzes TLR2-mediated immune signaling in cells exposed to cytomegalovirus glycoprotein B. This immunologic impairment could serve as a biologic mechanism underlying the association between the TLR2… (More)
DOI: 10.1086/644501


1 Figure or Table