The R5 to X4 coreceptor switch


In this paper, we show how a game theoretic analysis can provide a model to explain the interdependence of host produced APOBEC3G levels and limited X4 transmission. From our analysis, we show that when APOBEC3G strongly favors mutation from an R5 strain to an X4 strain, it can be optimal for the HIV-1 virus to suppress transmission of the X4 variant… (More)

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