The Quintiles Prize Lecture 2004: The identification of the adenosine A2B receptor as a novel therapeutic target in asthma

@article{Holgate2005TheQP,
  title={The Quintiles Prize Lecture 2004: The identification of the adenosine A2B receptor as a novel therapeutic target in asthma},
  author={S. Holgate},
  journal={British Journal of Pharmacology},
  year={2005},
  volume={145}
}
  • S. Holgate
  • Published 2005
  • Medicine
  • British Journal of Pharmacology
  • Adenosine is a powerful bronchoconstrictor of asthmatic, but not normal, airways. In vitro studies on isolated human mast cells and basophils revealed that adenosine and selective analogues augmented inflammatory mediator release from mast cells by stimulating A2 receptors. Pharmacological blockade of mast cell mediator release in vivo also attenuated adenosine‐induced bronchoconstriction, as did theophylline, by adenosine A2 receptor antagonism. Further in vitro studies revealed that the… CONTINUE READING
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