The Quantitative Genetics of Phenotypic Robustness

@inproceedings{Fraser2010TheQG,
  title={The Quantitative Genetics of Phenotypic Robustness},
  author={H. B. Fraser and Eric E. Schadt},
  booktitle={PloS one},
  year={2010}
}
Phenotypic robustness, or canalization, has been extensively investigated both experimentally and theoretically. However, it remains unknown to what extent robustness varies between individuals, and whether factors buffering environmental variation also buffer genetic variation. Here we introduce a quantitative genetic approach to these issues, and apply this approach to data from three species. In mice, we find suggestive evidence that for hundreds of gene expression traits, robustness is… CONTINUE READING

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