The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

@article{Bell2007TheQS,
  title={The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production},
  author={Eric L. Bell and Tatyana A. Klimova and James Eisenbart and Carlos T Moraes and Michael P Murphy and G. R. Scott Budinger and Navdeep S Chandel},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={177},
  pages={1029 - 1036}
}
Mammalian cells increase transcription of genes for adaptation to hypoxia through the stabilization of hypoxia-inducible factor 1alpha (HIF-1alpha) protein. How cells transduce hypoxic signals to stabilize the HIF-1alpha protein remains unresolved. We demonstrate that cells deficient in the complex III subunit cytochrome b, which are respiratory incompetent, increase ROS levels and stabilize the HIF-1alpha protein during hypoxia. RNA interference of the complex III subunit Rieske iron sulfur… CONTINUE READING
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