The QT syndromes: long and short

@article{Morita2008TheQS,
  title={The QT syndromes: long and short},
  author={Hiroshi Morita and Jiashin Wu and Douglas P. Zipes},
  journal={The Lancet},
  year={2008},
  volume={372},
  pages={750-763}
}
This Seminar presents the most recent information about the congenital long and short QT syndromes, emphasising the varied genotype-phenotype association in the ten different long QT syndromes and the five different short QT syndromes. Although uncommon, these syndromes serve as a Rosetta stone for the understanding of inherited ion-channel disorders leading to life-threatening cardiac arrhythmias. Ionic abnormal changes mainly affecting K(+), Na(+), or Ca(2+) currents, which either prolong or… Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
This report shows that a combination of blockers of the potassium urrents and/or enhancers of the late sodium current in experimenal models reproduced clinical phenotypes of compound mutations of acquired long QT syndrome. Expand
Transgenic rabbit models to investigate the cardiac ion channel disease long QT syndrome.
TLDR
A review of the advantages and shortcomings of different drug-induced and genetically mediated LQTS animal models - focusing on mouse and rabbit models since these represent the most commonly used small animal models for LQ TS that can be subjected to genetic manipulation. Expand
Determinants of incomplete penetrance and variable expressivity in heritable cardiac arrhythmia syndromes.
TLDR
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