The QT interval and the atypical antipsychotic, sertindole.

  title={The QT interval and the atypical antipsychotic, sertindole.},
  author={J{\"u}rgen Fritze and Borwin Bandelow},
  journal={International journal of psychiatry in clinical practice},
  volume={2 4},
Sertindole is a limbic-selective antipsychotic agent with a strong affinity for D2, 5-HT2 and α1-adrenergic receptors. Prolongation of the QT interval and other adverse cardiac or cardiovascular reactions are known effects of most antipsychotic drugs. For this reason such effects have been extensively monitored during clinical trials of sertindole. A small proportion of sertindole-treated patients were found to exhibit an increase in QT interval. Detailed analysis revealed no increased risk… CONTINUE READING

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