The Q192R polymorphism of the paraoxonase 1 gene is a risk factor for coronary artery disease in Saudi subjects

@article{Hassan2013TheQP,
  title={The Q192R polymorphism of the paraoxonase 1 gene is a risk factor for coronary artery disease in Saudi subjects},
  author={Mohammed Amir Hassan and Omar Salem Al-Attas and Tajamul Hussain and Nasser Mohammad Al-Daghri and Majed Saleh Alokail and Abdul Khader Mohammed and Benjamin Vinodson},
  journal={Molecular and Cellular Biochemistry},
  year={2013},
  volume={380},
  pages={121-128}
}
Paraoxonase-1 (PON1) is a HDL-bound antioxidant enzyme that protects LDL from oxidative modification. Discovery of the antioxidant properties of PON1 led to extensive research on its role in the initiation and progression of atherosclerosis. The Q192R (rs662; A/G) polymorphism, which results in the glutamine to arginine substitution at position 192, of the PON1 gene has been linked to increased atherosclerosis risk in several but not all population studies. Besides genetic factors… CONTINUE READING

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The relationship between paraoxonase1-192 polymorphism and activity with coronary artery disease

RH Mohamed, RA Karam, TA Abd El-Aziz
ClinBiochem • 2010
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