The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis.

@article{Tanner2003TheQM,
  title={The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis.},
  author={N. Kyle Tanner and Olivier Cordin and Josette Banroques and Monique Do{\`e}re and Patrick Linder},
  journal={Molecular cell},
  year={2003},
  volume={11 1},
  pages={127-38}
}
SF1 and SF2 helicases have structurally conserved cores containing seven to eight distinctive motifs and variable amino- and carboxyl-terminal flanking sequences. We have discovered a motif upstream of motif I that is unique to and characteristic of the DEAD box family of RNA helicases. It consists of a 9 amino acid sequence containing an invariant glutamine. A conserved phenylalanine occurs 17 aa further upstream. Sequence alignments, site-specific mutagenesis, and ATPase assays show that this… CONTINUE READING
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