The Pungency of Garlic: Activation of TRPA1 and TRPV1 in Response to Allicin

@article{Macpherson2005ThePO,
  title={The Pungency of Garlic: Activation of TRPA1 and TRPV1 in Response to Allicin},
  author={Lindsey J. Macpherson and Bernhard Hubert Geierstanger and Veena Viswanath and Michael Bandell and Samer R. Eid and Sun Aie Hwang and Ardem Patapoutian},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={929-934}
}

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References

SHOWING 1-10 OF 34 REFERENCES

Intake of garlic and its bioactive components.

TLDR
The health benefits of garlic likely arise from a wide variety of components, possibly working synergistically, and ample research suggests that several bioavailable components likely contribute to the observed beneficial effects.

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

TLDR
It is shown that mustard oil depolarizes a subpopulation of primary sensory neurons that are also activated by capsaicin, the pungent ingredient in chilli peppers, and by Δ9-tetrahydrocannabinol, the psychoactive component of marijuana.

Anticarcinogenic Properties of Garlic: A Review

TLDR
The formulation of odorless functional foods with the retention of anticarcinogenic activity should be further studied and the dosage of garlic and type should be standardized.

The capsaicin receptor: a heat-activated ion channel in the pain pathway

TLDR
The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.

Impaired nociception and pain sensation in mice lacking the capsaicin receptor.

TLDR
Sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli and are impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation.

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

TLDR
These findings, together with the previous identification of the heat-sensitive channels VR1 and VRL-1, demonstrate that TRP channels detect temperatures over a wide range and are the principal sensors of thermal stimuli in the mammalian peripheral nervous system.