The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

  title={The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.},
  author={Elizabeth C. Townsend and Mark A. Murakami and Alexandra Christodoulou and Amanda L. Christie and Johannes K{\"o}ster and Tiffany A Desouza and Elizabeth A Morgan and Scott Kallgren and Huiyun Liu and Shuo-Chieh Wu and Olivia Plana and Joan Montero and Kristen E. Stevenson and Prakash K. Rao and Raga Vadhi and Michael Andreeff and Philippe F Armand and Karen Kuhn Ballen and Patrizia Barzaghi-Rinaudo and Sarah Cahill and Rachael A Clark and Vesselina G. Cooke and Matthew S. Davids and Daniel J. Deangelo and David M Dorfman and Hilary Eaton and Benjamin L. Ebert and Julia Etchin and Brant Firestone and David C. Fisher and Arnold Stephen Freedman and Ilene Galinsky and Hui Gao and Jacqueline S. Garcia and Francine Garnache-Ottou and Timothy A. Graubert and Alejandro Gutierrez and Ensar Halilovic and Marian H. Harris and Zachary Herbert and Steven M Horwitz and Giorgio Inghirami and Andrew M Intlekofer and Moriko Ito and Shai Izraeli and Eric D. Jacobsen and Caron A. Jacobson and S{\'e}bastien Jeay and Irmela Jeremias and Michelle A Kelliher and Raphael Koch and Marina Y Konopleva and Nadja Kopp and Steven M. Kornblau and Andrew L Kung and Thomas S Kupper and Nicole R Leboeuf and Ann S Lacasce and Emma Lees and Loretta S Li and A Thomas Look and Masato Murakami and Markus Muschen and Donna S Neuberg and Samuel Yao-Ming Ng and Oreofe O Odejide and Stuart H Orkin and Rachel R Paquette and Andrew E Place and Justine E. Roderick and Jeremy A Ryan and Stephen E. Sallan and Brent Shoji and Lewis B. Silverman and Robert J. Soiffer and David P Steensma and Kimberly Stegmaier and Richard M Stone and J{\'e}r{\^o}me Tamburini and Aaron R. Thorner and Paul van Hummelen and Martha Wadleigh and Marion Wiesmann and Andrew P. Weng and Jens W{\"u}rthner and David A Williams and Bruce M. Wollison and Andrew A. Lane and Anthony Letai and Monica M. Bertagnolli and Jerome Ritz and Myles Brown and Henry W. Long and Jon C Aster and Margaret A Shipp and James D Griffin and David M. Weinstock},
  journal={Cancer cell},
  volume={29 4},
More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors. To address this hypothesis, we established a large, publicly available repository of well-characterized leukemia and lymphoma PDXs that undergo orthotopic engraftment, called the Public Repository of Xenografts (PRoXe… CONTINUE READING

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