The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis

@article{Dsouza2004ThePE,
  title={The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis},
  author={Deepak Cyril D'souza and Edward Perry and Lisa Macdougall and Yola Ammerman and Thomas Cooper and Yu-Te Wu and Gabriel Braley and Ralitza Gueorguieva and John H. Krystal},
  journal={Neuropsychopharmacology},
  year={2004},
  volume={29},
  pages={1558-1572}
}
Recent advances in the understanding of brain cannabinoid receptor function have renewed interest in the association between cannabinoid compounds and psychosis. In a 3-day, double-blind, randomized, and counterbalanced study, the behavioral, cognitive, and endocrine effects of 0, 2.5, and 5 mg intravenous delta-9-tetrahydrocannabinol (Δ-9-THC) were characterized in 22 healthy individuals, who had been exposed to cannabis but had never been diagnosed with a cannabis abuse disorder. Prospective… CONTINUE READING
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