The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment.

@article{Diggle2007ThePA,
  title={The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment.},
  author={S. Diggle and S. Matthijs and V. Wright and Matthew P. Fletcher and S. R. Chhabra and I. Lamont and Xiaole Kong and R. Hider and P. Cornelis and M. C{\'a}mara and P. Williams},
  journal={Chemistry \& biology},
  year={2007},
  volume={14 1},
  pages={
          87-96
        }
}
Pseudomonas aeruginosa produces 2-heptyl-3-hydroxy-4(1H)-quinolone (PQS), a quorum-sensing (QS) signal that regulates numerous virulence genes including those involved in iron scavenging. Biophysical analysis revealed that 2-alkyl-3-hydroxy-4-quinolones form complexes with iron(III) at physiological pH. The overall stability constant of 2-methyl-3-hydroxy-4-quinolone iron(III) complex was log beta(3) = 36.2 with a pFe(3+) value of 16.6 at pH 7.4. PQS was found to operate via at least three… Expand

Paper Mentions

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TLDR
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TLDR
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The PQS system is focused on, from its discovery to its role in Pseudomonas pathogenesis, such as iron depletion and pyocyanin synthesis that involves the PqsE protein - an intriguing player of this system. Expand
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