The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization.

@article{Teichmann2012ThePS,
  title={The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization.},
  author={Anke Teichmann and Claudia Rutz and Annika Kreuchwig and Gerd Krause and Burkhard Wiesner and Ralf Schuelein},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 32},
  pages={
          27265-74
        }
}

• Anke Teichmann, Claudia Rutz, +3 authors Ralf Schuelein
• Published 2012 in The Journal of biological chemistry
• DOI:10.1074/jbc.M112.360594

N-terminal signal peptides mediate the interaction of native proteins with the translocon complex of the endoplasmic reticulum membrane and are cleaved off during early protein biogenesis. The corticotropin-releasing factor receptor type 2a (CRF(2(a))R) possesses an N-terminal pseudo signal peptide, which represents a so far unique domain within the large protein family of G protein-coupled receptors (GPCRs). In contrast to a conventional signal peptide, the pseudo signal peptide remains… CONTINUE READING

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