The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization.

@article{Teichmann2012ThePS,
  title={The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization.},
  author={Anke Teichmann and Claudia Rutz and Annika Kreuchwig and Gerd Krause and Burkhard Wiesner and Ralf Schuelein},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 32},
  pages={
          27265-74
        }
}
N-terminal signal peptides mediate the interaction of native proteins with the translocon complex of the endoplasmic reticulum membrane and are cleaved off during early protein biogenesis. The corticotropin-releasing factor receptor type 2a (CRF(2(a))R) possesses an N-terminal pseudo signal peptide, which represents a so far unique domain within the large protein family of G protein-coupled receptors (GPCRs). In contrast to a conventional signal peptide, the pseudo signal peptide remains… CONTINUE READING
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Simultaneous two-photon excitation of distinct labels for dual-color fluorescence crosscorrelation analysis.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 16 Excerpts
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