The Prvention of Perinatal Transmission of Hepatitis B Virus (hbv) Infection: a Comparison of Two Prophylactic Schedules

Abstract

During the two year period 1986/87, 271 babies were born to hepatitis B surface atigen carrier mothers in the English West Midlands. Babies were allocated sequentially into either treatment Group A (4 doses of HBVax, Merck Sharp & Dohme, 10 mcg. i.m, at birth, 1, 2 and 6 months) or treatment Group B (250 I.U. hepatitis B immunoglobulin (HBIG) at birth, combined with the same vaccine schedule as Group A). 172 babies were enrolled and data was available for analysis on 150 (87%).Results:ConclusionsIn circumstances in which HBIG is not available a 4 dose vaccine schedule can protect at risk infants from perinatal transmission of HBV. In babies born to the less infectious carrier mothers in our study (i.e. those not HBe Ag+) the addition of HBIG to the schedule conferred no added benefit. In infants born to HBe Ag+ mothers protection was enhanced by addition of HBIG although transmission was still not prevented in every case. In utero infection and slow response to vaccine may be implicated failure mechanisms.

DOI: 10.1203/00006450-198909000-00061

Cite this paper

@article{Wheeley1989ThePO, title={The Prvention of Perinatal Transmission of Hepatitis B Virus (hbv) Infection: a Comparison of Two Prophylactic Schedules}, author={S M Wheeley and Elizabeth H Boxall and Michael Tarlow}, journal={Pediatric Research}, year={1989}, volume={26}, pages={273-273} }