The Proton-Pump Inhibitor Lansoprazole Enhances Amyloid Beta Production

@inproceedings{Badiola2013ThePI,
  title={The Proton-Pump Inhibitor Lansoprazole Enhances Amyloid Beta Production},
  author={Nahuai Badiola and Victor Alcalde and Albert Pujol and Lisa-Marie M{\"u}nter and Gerd Multhaup and Alberto Lle{\'o} and Mireia Coma and Montserrat Soler-Lopez and Patrick Aloy},
  booktitle={PloS one},
  year={2013}
}
A key event in the pathogenesis of Alzheimer's disease (AD) is the accumulation of amyloid-β (Aβ) species in the brain, derived from the sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. Based on a systems biology study to repurpose drugs for AD, we explore the effect of lansoprazole, and other proton-pump inhibitors (PPIs), on Aβ production in AD cellular and animal models. We found that lansoprazole enhances Aβ37, Aβ40 and Aβ42 production and lowers Aβ38… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 43 CITATIONS

Risk of dementia in elderly patients with the use of proton pump inhibitors

  • European Archives of Psychiatry and Clinical Neuroscience
  • 2014
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Advantages and Disadvantages of Long-term Proton Pump Inhibitor Use

  • Journal of neurogastroenterology and motility
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

Lack of Association Between Proton Pump Inhibitor Use and Cognitive Decline.

  • Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2018

References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES

Methods and Systems for identifying molecules or processes of biological interest by using knowledge discovery in biological data. Patent

J Mas, A Pujol, J Farrés, P Aloy
  • United States of America
  • 2010
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Drug evaluation: (R)-flurbiprofen--an enantiomer of flurbiprofen for the treatment of Alzheimer's disease.

  • IDrugs : the investigational drugs journal
  • 2007
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

The metalloprotease meprin beta generates amino terminal truncated Abeta-peptide species

J Bien, T Jefferson, M Causevic, T Jumpertz, L Muenter
  • J Biol Chem
  • 2012
VIEW 1 EXCERPT

New combination therapies for treating neurological disorders. Patent

M Coma, A Pujol, F Gomis, B Oliva, A Lleó
  • United States of America
  • 2011