• Medicine
• Published in PloS one 2013
• DOI:10.1371/journal.pone.0058837

The Proton-Pump Inhibitor Lansoprazole Enhances Amyloid Beta Production

@inproceedings{Badiola2013ThePI,
  title={The Proton-Pump Inhibitor Lansoprazole Enhances Amyloid Beta Production},
  author={Nahuai Badiola and Victor Alcalde and Albert Pujol and Lisa-Marie M{\"u}nter and Gerd Multhaup and Alberto Lle{\'o} and Mireia Coma and Montserrat Soler-Lopez and Patrick Aloy},
  booktitle={PloS one},
  year={2013}
}

• Nahuai Badiola, Victor Alcalde, +6 authors Patrick Aloy

A key event in the pathogenesis of Alzheimer's disease (AD) is the accumulation of amyloid-β (Aβ) species in the brain, derived from the sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. Based on a systems biology study to repurpose drugs for AD, we explore the effect of lansoprazole, and other proton-pump inhibitors (PPIs), on Aβ production in AD cellular and animal models. We found that lansoprazole enhances Aβ37, Aβ40 and Aβ42 production and lowers Aβ38… CONTINUE READING

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