The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

  title={The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4},
  author={I -Ching Ho and Martin R. Hodge and John W. Rooney and L. H. Glimcher},
The molecular basis for the distinctive cytokine expression of CD4+ T helper 1 (Th1) and T helper 2 (Th2) subsets remains elusive. Here, we report that the proto-oncogene c-maf, a basic region/leucine zipper transcription factor, controls tissue-specific expression of IL-4. c-Maf is expressed in Th2 but not Th1 clones and is induced during normal precursor cell differentiation along a Th2 but not Th1 lineage. c-Maf binds to a c-Maf response element (MARE) in the proximal IL-4 promoter adjacent… CONTINUE READING
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MafB is an interaction partner and repressor of Ets - 1 that inhibits erythroidsites and form heterodimers with fos and jun

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