The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

@article{Ho1996ThePC,
  title={The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4},
  author={I -Ching Ho and Martin R. Hodge and John W. Rooney and L. H. Glimcher},
  journal={Cell},
  year={1996},
  volume={85},
  pages={973-983}
}
The molecular basis for the distinctive cytokine expression of CD4+ T helper 1 (Th1) and T helper 2 (Th2) subsets remains elusive. Here, we report that the proto-oncogene c-maf, a basic region/leucine zipper transcription factor, controls tissue-specific expression of IL-4. c-Maf is expressed in Th2 but not Th1 clones and is induced during normal precursor cell differentiation along a Th2 but not Th1 lineage. c-Maf binds to a c-Maf response element (MARE) in the proximal IL-4 promoter adjacent… CONTINUE READING
Highly Influential
This paper has highly influenced 17 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 254 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

MafB is an interaction partner and repressor of Ets - 1 that inhibits erythroidsites and form heterodimers with fos and jun

  • T. K. Kerppola, T. Curran, M. H. Sieweke, H. Tekotte, J. Frampton, T. Graf
  • Oncogene
  • 1996

Similar Papers

Loading similar papers…