The Proto‐Oncogene Myc Is Essential for Mammary Stem Cell Function

@article{Moumen2012ThePM,
  title={The Proto‐Oncogene Myc Is Essential for Mammary Stem Cell Function},
  author={M. Moumen and A. Chiche and M. Deugnier and V. Petit and A. Gandarillas and M. Glukhova and Marisa M. Faraldo},
  journal={STEM CELLS},
  year={2012},
  volume={30}
}
  • M. Moumen, A. Chiche, +4 authors Marisa M. Faraldo
  • Published 2012
  • Biology, Medicine
  • STEM CELLS
  • The mammary epithelium comprises two major cell lineages: basal and luminal. Basal cells (BCs) isolated from the mammary epithelium and transplanted into the mouse mammary fat pad cleared from the endogenous epithelium regenerate the mammary gland, strongly suggesting that the basal epithelial compartment harbors a long‐lived cell population with multipotent stem cell potential. The luminal cell layer is devoid of the regenerative potential, but it contains cells with clonogenic capacity, the… CONTINUE READING
    Myc is required for β-catenin-mediated mammary stem cell amplification and tumorigenesis
    • 45
    • Open Access

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 38 REFERENCES
    Distinct stem cells contribute to mammary gland development and maintenance
    • 641
    • Open Access
    Purification and unique properties of mammary epithelial stem cells
    • 1,443
    Generation of a functional mammary gland from a single stem cell
    • 1,838
    • Open Access