The Proteome of the Isolated Chlamydia trachomatis Containing Vacuole Reveals a Complex Trafficking Platform Enriched for Retromer Components

@inproceedings{Aeberhard2015ThePO,
  title={The Proteome of the Isolated Chlamydia trachomatis Containing Vacuole Reveals a Complex Trafficking Platform Enriched for Retromer Components},
  author={Lukas Aeberhard and Sebastian Banhart and Martina Fischer and Nico Jehmlich and Laura A. Rose and Sophia Koch and Michael Laue and Bernhard Y. Renard and Frank Schmidt and Dagmar Heuer and Michael N. Starnbach},
  booktitle={PLoS pathogens},
  year={2015}
}
Chlamydia trachomatis is an important human pathogen that replicates inside the infected host cell in a unique vacuole, the inclusion. The formation of this intracellular bacterial niche is essential for productive Chlamydia infections. Despite its importance for Chlamydia biology, a holistic view on the protein composition of the inclusion, including its membrane, is currently missing. Here we describe the host cell-derived proteome of isolated C. trachomatis inclusions by quantitative… CONTINUE READING
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