The ProteoMiner in the proteomic arena: a non-depleting tool for discovering low-abundance species.

@article{Boschetti2008ThePI,
  title={The ProteoMiner in the proteomic arena: a non-depleting tool for discovering low-abundance species.},
  author={Egisto Boschetti and Pier Giorgio Righetti},
  journal={Journal of proteomics},
  year={2008},
  volume={71 3},
  pages={255-64}
}
Combinatorial ligand libraries, composed by millions of hexapeptides, are here reviewed in terms of their ability of capturing the low-abundance proteome. First, the physico-chemical properties of such libraries are dealt with, especially in regard to the proper length of the bait. The capturing ability of single amino acids has been assessed demonstrating that there exist a protein adsorption capability dichotomy, by which 8 amino acids (Arg, Lys, His, Phe, Tyr, Trp, Val and Leu) are… CONTINUE READING
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