The Protein Product of the c - cb ! Protooncogene Is Phosphorylated after B Cell Receptor Stimulation and Binds the SH 3 Domain of Bruton ' s Tyrosine Kinase

Abstract

X-linked agammaglobulinemia, a B cell immunodeficiency, is caused by mutations in the Bruton's tyrosine kinase (Btk) gene. The absence of a functional Btk protein leads to a failure of B cell differentiation and antibody production. B cell receptor stimulation leads to the phosphorylation of the Btk protein and it is, therefore, likely that Btk is involved… (More)

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@inproceedings{Cory1995ThePP, title={The Protein Product of the c - cb ! Protooncogene Is Phosphorylated after B Cell Receptor Stimulation and Binds the SH 3 Domain of Bruton ' s Tyrosine Kinase}, author={Giles O. C. Cory and Ruth C. Lovering and Steve Hinshelwood and Lucy Maccarthy-Morrogh and Roland J. Levinsky and Christine Kinnon}, year={1995} }