The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification

@inproceedings{Brownlee2011ThePP,
  title={The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification},
  author={Christopher W Brownlee and Joey E. Klebba and Daniel W Buster and Gregory C Rogers},
  booktitle={The Journal of cell biology},
  year={2011}
}
Centriole duplication is a tightly regulated process that must occur only once per cell cycle; otherwise, supernumerary centrioles can induce aneuploidy and tumorigenesis. Plk4 (Polo-like kinase 4) activity initiates centriole duplication and is regulated by ubiquitin-mediated proteolysis. Throughout interphase, Plk4 autophosphorylation triggers its degradation, thus preventing centriole amplification. However, Plk4 activity is required during mitosis for proper centriole duplication, but the… CONTINUE READING

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