The Protein Kinase Complement of the Human Genome

@article{Manning2002ThePK,
  title={The Protein Kinase Complement of the Human Genome},
  author={Gerard Manning and David B. Whyte and Raquel Martinez and Tony Hunter and Sucha Sudarsanam},
  journal={Science},
  year={2002},
  volume={298},
  pages={1912 - 1934}
}
We have catalogued the protein kinase complement of the human genome (the "kinome") using public and proprietary genomic, complementary DNA, and expressed sequence tag (EST) sequences. [...] Key Result We identify 518 putative protein kinase genes, of which 71 have not previously been reported or described as kinases, and we extend or correct the protein sequences of 56 more kinases.Expand
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TLDR
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TLDR
The mining of public databases to collect the sequence information of all identified human kinase genes and the cloning of the corresponding ORFs is described, which will facilitate the functional assaying of this important gene family in phenotypic screens and their use in biochemical and structural studies. Expand
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TLDR
Most members of a protein kinase family have the same set of ancillary domains, but there are some exceptions, and alternative splicing is often used to generate distinct domain combinations from a single gene. Expand
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TLDR
A systematic classification of kinases based on the bioinformatic analysis of their expression in human tissues and diseases is reported, as well as grouping of tissues and tumor types according to the similarity of their kinome transcription. Expand
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