The Protective Effect of Soybean and Thyme on Iron Deficiency Anemia in Rats

  title={The Protective Effect of Soybean and Thyme on Iron Deficiency Anemia in Rats},
  author={Nora M. El-Sheikh},
  journal={The Egyptian Journal of Hospital Medicine},
  • N. M. El-Sheikh
  • Published 1 October 2008
  • Biology
  • The Egyptian Journal of Hospital Medicine
Objective: The present study is carried out to investigate the protective effect and antioxidant activity of soybean and thyme on iron deficiency anemia. [] Key Method All three iron sources provide 35 mg iron/kg diet. At the end of experiment (49 days), rats were anesthetized, whole blood was used for determination of hemoglobin (Hb), hematocrit (HCt) and reduced glutathione (GSH) levels. Serum was used for determination of iron and lipid profile as well as lipid peroxidation as malondialdehyde (MDA).
The objective of this work to study the therapeutic effect of volatile oils and alcoholic aqueous extracts of basil and thyme leaves in blood glucose and lipid profile of alloxan- induced in diabetic
The haemoglobin regeneration potential of fermented and unfermented Telfaira occidentalis and Gnetum africanum leaves in iron deficient albino rats
The effect of 10% supplementation of fermented and unfermented Telfaira occidentalis and Gnetum africanum leaves for 21 days on haemoglobin-iron, haematological parameters and serum ferritin was


Effect of Indonesian Fermented Soybean Tempeh on Iron Bioavailability and Lipid Peroxidation in Anemic Rats
The effects of an Indonesian non-salted fermented soybean product, tempeh, on iron bioavailability and lipid peroxidation are suspected to contribute to iron deficiency. Three groups of
Both iron deficiency and daily iron supplements increase lipid peroxidation in rats.
It is concluded that iron deficiency results in lipid peroxidation, but that its correction with daily iron supplements results in abnormal iron accumulation and increased lipid per oxidation in rats, which are mitigated by intermittent iron supplementation.
Lipid peroxidation and activities of antioxidant enzymes in iron deficiency and effect of carcinogen feeding.
Iron deficiency and marginal vitamin A deficiency affect growth, hematological indices and the regulation of iron metabolism genes in rats.
Although marginal VA deficiency did not exacerbate indices of poor iron status during iron deficiency, iron deficiency was associated with lower plasma retinol and elevated liver VA concentrations, consistent with an impaired mobilization of liver Retinol during Iron deficiency as well as multiple alterations in iron metabolism.
Iron intake influences essential fatty acid and lipid composition of rat plasma and erythrocytes.
The fatty acid and lipid data suggest a mild impairment in essential fatty acid metabolism in moderately iron-deficient rats and a significant alteration in the total lipid content of plasma and erythrocytes of iron-supplemented rats.
Supplementation with α-tocopherol or a combination of α-tocopheroland ascorbic acid protects the gastrointestinal tract of iron-deficientrats against iron-induced oxidative damage during iron repletion
It was observed that though the indicators of Fe status were normalised on Fe supplementation, the oxidative stress as reflected by the levels of both thiobarbituric-acid reactive substances (TBARS) and protein carbonyls were significantly greater in D+ and D+ + C compared to D- + E, D+ = C + E and Con groups, which could be due to the protection offered by α-tocopherol in the presence of Fe.
Superoxide dismutase and glutathione peroxidase in erythrocytes of patients with iron deficiency anemia: effects of different treatment modalities.
Oral iron treatment improved the iron deficiency anemia and recovered antioxidant defense system by increasing SOD activity and maintaining GSH-Px activity at normal level and vitamin E supplementation together with PI treatment may be effective in partially restoring the antioxidant status in this type of anemia.
Effect of iron supplementation on oxidative stress and antioxidant status in iron-deficiency anemia
After 6 wk of iron supplementation, a significant decrease of oxidative stress was observed in the treated subjects relative to controls, and no significant differences existed between treated patients at 6 wK and at the end of the study.
Glutathione peroxidase activity in iron-deficient rats.
The data suggest that GSH-Px is present in adequate quantities in iron-deficient red blood cells to protect cell membranes and hemoglobin as long as the rats receive adequate Se.