The Protective Effect of Glibenclamide in a Model of Hemorrhagic Encephalopathy of Prematurity

@inproceedings{Tosun2013ThePE,
  title={The Protective Effect of Glibenclamide in a Model of Hemorrhagic Encephalopathy of Prematurity},
  author={Cigdem Tosun and Michael T. Koltz and David Kurland and Hina Ijaz and Melda Gurakar and Gary Schwartzbauer and Turhan Coksaygan and Sa{\vs}ka Ivanova and Volodymyr Gerzanich and J. Marc Simard},
  booktitle={Brain sciences},
  year={2013}
}
We studied a model of hemorrhagic encephalopathy of prematurity (EP) that closely recapitulates findings in humans with hemorrhagic EP. This model involves tandem insults of 20 min intrauterine ischemia (IUI) plus an episode of elevated venous pressure induced by intraperitoneal glycerol on post-natal day (P) 0. We examined Sur1 expression, which is upregulated after focal ischemia but has not been studied after brief global ischemia including IUI. We found that 20 min IUI resulted in robust… CONTINUE READING

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