The Protective Activity of Tea Catechins against Experimental Infection by Vibrio cholerae O1

  title={The Protective Activity of Tea Catechins against Experimental Infection by Vibrio cholerae O1},
  author={Masako Toda and Sachie Okubo and Hajime Ikigai and T. Suzuki and Y. Suzuki and Yukihiko Hara and Tadakatsu Shimamura},
  journal={Microbiology and Immunology},
Tea catechins inhibited the fluid accumulation induced by cholera toxin in sealed adult mice. The catechins also reduced fluid accumulation by Vibrio cholerae O1 in ligated intestinal loops of rabbits. These findings suggest that tea catechins may possess protective activity against V. cholerae O1. 

Protective Effect of Japanese Green Tea Extract on Gnotobiotic Mice Infected with an Escherichia coli O157:H7 Strain

The Shiga‐like toxin (SLT) level in the feces of the JGTE diet group was significantly lower than that of the control group, which indicates the inhibition of bacterial growth in vivo.

Inhibition of virulence potential of Vibrio cholerae by natural compounds

The quantitative reverse transcription real-time PCR assay revealed that capsaicin dramatically reduced the expression of major virulence-related genes such as ctxA, tcpA and toxT but enhanced the expressionof hns gene that transcribes a global prokaryotic gene regulator (H-NS) which indicates that the repression of CT production by capsicin or red chili might be due to the suppression of virulence genes transcription by H-NS.

Inhibitory effect of catechin against the superantigen staphylococcal enterotoxin B (SEB)

Investigation of the inhibitory effect of the green tea catechin extract, Polyphenon, and (−)-epigallocatechin gallate on staphylococcal enterotoxin B and its mechanisms of action finds inhibition of SsAg-induced T-cell activation by cATEchin was observed in both in vivo and in vitro studies, suggesting that cate chin may be useful in the treatment of AD.

Anti‐Helicobacter pylori activity of Chinese tea: in vitro study

  • Y. YeeM. Koo
  • Biology, Medicine
    Alimentary pharmacology & therapeutics
  • 2000
Chinese tea has an antibacterial activity against a wide range of bacteria. However, its activity against Helicobacter pylori has not been reported.

Development of a Novel Herbal Formulation To Inhibit Biofilm Formation in Toxigenic Vibrio cholerae.

It is proposed that these herbal combinations could serve as a multifaceted approach to combat the pathogen and also, in turn, reduce antimicrobial resistance development.

Anti‐Helicobacter pylori Activities of Six Iranian Plants

This work has shown that plants seem to be a logical source of new antibacterial compounds for Helicobacter pylori infections, and development of drug resistance in bacteria calls for new sources of drugs, and plants seem the logical source.

Identification in traditional herbal medications and confirmation by synthesis of factors that inhibit cholera toxin-induced fluid accumulation

  • H. OiD. Matsuura M. Noda
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2002
Kampo formulations or their gallate components might be effective adjunctive therapy with oral rehydration solution for the severe diarrhea of cholera.

9 Structure Based Design of Cholera Toxin Antagonists Č

Some examples of structure based design of various types of CT inhibitors are shown, including catechin-like compounds as inhibitors of the enzymatic A unit of CT; mimics of oGM1 as inhibitor of the non-toxic pentamer of B subunits of CT (CTB); as well as multivalent inhibitors that very effectively prevent adhesion of CTB to GM1 receptors at the surface of epithelial cells are described.

Anticytotoxic Effect of Green Tea Catechin on Aggregatibacter actinomycetemcomitans Vesicles

The results suggest that the inhibitory mechanisms of catechin on cytotoxic activity could result in the inhibition of binding vesicles to cells by catechins because the catechchin component binds to the vesicle.

Potential Antimicrobial Properties of Coffee Beans and Coffee By-Products Against Drug-Resistant Vibrio cholerae

Vibrio cholerae is the causative organism of the cholera epidemic, and it remains a serious global health problem, particularly the multidrug-resistant strain, despite the development of several



The protective activity of tea against infection by Vibrio cholerae O1.

Findings suggest that tea has protective activity against V. cholerae O1, and that tea extract reduced fluid accumulation induced by cholera toxin in sealed adult mice and in ligated intestinal loops of rabbits.

The bactericidal activity of tea and coffee

Extracts of black tea, green tea, pu‐erh tea or coffee inhibited the growth of various bacteria known to cause diarrhoeal diseases. Tea or coffee also showed bactericidal activity against

The anti‐haemolysin activity of tea and coffee

Extracts of tea and coffee inhibited the haemolytic activities of Staphylococcus aureusα‐toxin and Vibrio parahaemolyticus thermostable direct haemolysin (Vp‐TDH). Black tea had the strongest

Experimental cholera in infant rabbits: a method for chemotherapeutic investigation.

"Vibrio choerae is shown to be effective in the treatment of mice experimentally inoculated with Vibrio Choerae.

[Antibacterial and bactericidal activities of Japanese green tea].

It was found that extracts of Japanese green tea leaves inhibited the growth of various bacteria causing diarrheal diseases and bactericidal activity over S. aureus, V. parahaemolyticus and even enteropathogenic E. coli which was not sensitive when tested by cup method.

[Antibacterial and anti-hemolysin activities of tea catechins and their structural relatives].

The results suggest that the catechol and pyrogallol groups are responsible for the antibacterial and bactericidal activities, while the conformation of catechins might play an important role in the anti-hemolysin activity.

[Relationship between the anti-hemolysin activity and the structure of catechins and theaflavins].

The tertiary structure of the catechin or theaflavin and the active site of hemolysin, that affects the interaction between them, plays an important role in the anti-hemolysin activity.

Sealed adult mice: new model for enterotoxin evaluation

Outbred, inbred, and congenic strains of conventional mice which were ano-rectally occluded with cyanoacrylate ester glue and converted to sealed adult mice (SAM) were given crude cholera enterotoxin in 10% NaHCO3 and showed fluid responses similar to those seen with low doses of CT.