The Propionic Acids: A Personal Perspective

@article{Adams1992ThePA,
  title={The Propionic Acids: A Personal Perspective},
  author={S. S. Adams},
  journal={The Journal of Clinical Pharmacology},
  year={1992},
  volume={32}
}
  • S. Adams
  • Published 1 April 1992
  • Medicine
  • The Journal of Clinical Pharmacology
In searching during the early 1950s for new drugs for the treatment of rheumatoid arthritis, little information was available to allow a rational approach. The mode of action of the few drugs available was unknown and even the analgesic action of aspirin could not be demonstrated in animals. A speculative concept was developed that aspirin possessed a specific unidentified action in rheumatoid arthritis and that this and its analgesic properties were related to its ability to delay the… 
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66 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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66 Citations

The medicinal chemistry of ibuprofen
In 1952 the research programme of Boots Pure Drug Company underwent a radical realignment under the new Research Director Dr. Gordon Hobday when attention was concentrated on ‘diseases of…
In Silico Evaluation of Ibuprofen and Two Benzoylpropionic Acid Derivatives with Potential Anti-Inflammatory Activity
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This in silico study evaluated the anti-inflammatory potential of two benzoylpropionic acid derivatives using molecular docking and their thermodynamic profiles by molecular dynamics, in addition to predicting oral bioavailability, bioactivity and toxicity.
Over-the-counter analgesics and antipyretics: a critical assessment.
The discovery and development of antiinflammatory drugs.
TLDR
Inflammation was one of the earliest recognized and defined disease entities and until the discovery of morphine, a drug effect was always the consequence of the combined ingredients of a plant or animal product and the suggestive effect of the “healer” (physician, apothecary, witch doctor).
Ab initio structural study of some substituted ibuprofen derivatives as possible anti-inflammatory agents
The formation energies of a series of substituted derivatives in - position of ibuprofen (2-p-isobutyl-phenyl-propionic acid) are determined, at the ab initio level RHF/6-311G** with full geometry…
[A short history of anti-rheumatic therapy. III. Non steroidal anti-inflammatory drugs].
TLDR
Progress derived from the discovery of the mechanism of action of these drugs: the inhibition of synthesis of prostaglandins due to the cycloxigenase enzyme system, according to the experimental contributions of John R. Vane.
Short-chain carboxylic-acid-stimulated, PMN-mediated gingival inflammation.
  • R. NiedermanJ. ZhangS. Kashket
  • Biology
    Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists
  • 1997
TLDR
The central hypothesis is that short-chain carboxylic acids can alter both cell function and gene expression, and thus contribute to the initiation and prolongation of gingival inflammation.
Disposition and covalent binding of ibuprofen and its acyl glucuronide in the elderly
The Use of Ibuprofen in the Treatment of Postoperative Pain in Dentistry
TLDR
The aim of this article was to present the most important pharmacological and therapeutic characteristics and side effects of ibuprofen used for postoperative pain treatment in dentistry.
Review on analgesic effect of co-administrated ibuprofen and caffeine
TLDR
Researchers showed that caffeine can be an effective analgesic adjuvant enhancing antinociceptive effect of ibuprofen in animals and humans and tablets containing well-soluble ib uprofen salt and caffeine could be easily prepared.
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