The Propionic Acids: A Personal Perspective

@article{Adams1992ThePA,
  title={The Propionic Acids: A Personal Perspective},
  author={S. S. Adams},
  journal={The Journal of Clinical Pharmacology},
  year={1992},
  volume={32}
}
  • S. Adams
  • Published 1992
  • Medicine
  • The Journal of Clinical Pharmacology
In searching during the early 1950s for new drugs for the treatment of rheumatoid arthritis, little information was available to allow a rational approach. The mode of action of the few drugs available was unknown and even the analgesic action of aspirin could not be demonstrated in animals. A speculative concept was developed that aspirin possessed a specific unidentified action in rheumatoid arthritis and that this and its analgesic properties were related to its ability to delay the… Expand
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62 Citations

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In 1952 the research programme of Boots Pure Drug Company underwent a radical realignment under the new Research Director Dr. Gordon Hobday when attention was concentrated on ‘diseases of… Expand
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In this article, Dr Adams gives his modest insight into the early stages and initial observations which led to this world-wide success of ibuprofen. Expand
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TLDR
Inflammation was one of the earliest recognized and defined disease entities and until the discovery of morphine, a drug effect was always the consequence of the combined ingredients of a plant or animal product and the suggestive effect of the “healer” (physician, apothecary, witch doctor). Expand
Ab initio structural study of some substituted ibuprofen derivatives as possible anti-inflammatory agents
The formation energies of a series of substituted derivatives in - position of ibuprofen (2-p-isobutyl-phenyl-propionic acid) are determined, at the ab initio level RHF/6-311G** with full geometry… Expand
[A short history of anti-rheumatic therapy. III. Non steroidal anti-inflammatory drugs].
TLDR
Progress derived from the discovery of the mechanism of action of these drugs: the inhibition of synthesis of prostaglandins due to the cycloxigenase enzyme system, according to the experimental contributions of John R. Vane. Expand
Choosing the Right Nonsteroidal Anti-Inflammatory Drug for the Right Patient
TLDR
The major differences between NSAIDs are their therapeutic half-lives and safety profiles, and individual patient-specific and NSAID-specific pharmacokinetic principles should be considered. Expand
Acyl glucuronides: the good, the bad and the ugly.
TLDR
A review of the intrinsic reactivity, metabolic stability and pharmacokinetic properties of acyl glucuronides in the context of physiological, pharmacological and toxicological perspectives concluded that these might be attenuated substantially in vivo by rapid clearance of the conjugates. Expand
Influence of piperine on ibuprofen induced antinociception and its pharmacokinetics.
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Piperine (10 mg/kg) significantly increased the dose-dependent antinociceptive activity of ibuprofen evaluated by both acetic acid writhing and formalin test, when it was administered with ib uprofen. Expand
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