The Propionic Acids: A Personal Perspective

  title={The Propionic Acids: A Personal Perspective},
  author={S. S. Adams},
  journal={The Journal of Clinical Pharmacology},
  • S. Adams
  • Published 1 April 1992
  • Medicine
  • The Journal of Clinical Pharmacology
In searching during the early 1950s for new drugs for the treatment of rheumatoid arthritis, little information was available to allow a rational approach. The mode of action of the few drugs available was unknown and even the analgesic action of aspirin could not be demonstrated in animals. A speculative concept was developed that aspirin possessed a specific unidentified action in rheumatoid arthritis and that this and its analgesic properties were related to its ability to delay the… 
The medicinal chemistry of ibuprofen
In 1952 the research programme of Boots Pure Drug Company underwent a radical realignment under the new Research Director Dr. Gordon Hobday when attention was concentrated on ‘diseases of
In Silico Evaluation of Ibuprofen and Two Benzoylpropionic Acid Derivatives with Potential Anti-Inflammatory Activity
This in silico study evaluated the anti-inflammatory potential of two benzoylpropionic acid derivatives using molecular docking and their thermodynamic profiles by molecular dynamics, in addition to predicting oral bioavailability, bioactivity and toxicity.
The discovery and development of antiinflammatory drugs.
Inflammation was one of the earliest recognized and defined disease entities and until the discovery of morphine, a drug effect was always the consequence of the combined ingredients of a plant or animal product and the suggestive effect of the “healer” (physician, apothecary, witch doctor).
Ab initio structural study of some substituted ibuprofen derivatives as possible anti-inflammatory agents
The formation energies of a series of substituted derivatives in - position of ibuprofen (2-p-isobutyl-phenyl-propionic acid) are determined, at the ab initio level RHF/6-311G** with full geometry
[A short history of anti-rheumatic therapy. III. Non steroidal anti-inflammatory drugs].
Progress derived from the discovery of the mechanism of action of these drugs: the inhibition of synthesis of prostaglandins due to the cycloxigenase enzyme system, according to the experimental contributions of John R. Vane.
Short-chain carboxylic-acid-stimulated, PMN-mediated gingival inflammation.
  • R. NiedermanJ. ZhangS. Kashket
  • Biology
    Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists
  • 1997
The central hypothesis is that short-chain carboxylic acids can alter both cell function and gene expression, and thus contribute to the initiation and prolongation of gingival inflammation.
The Use of Ibuprofen in the Treatment of Postoperative Pain in Dentistry
The aim of this article was to present the most important pharmacological and therapeutic characteristics and side effects of ibuprofen used for postoperative pain treatment in dentistry.
Review on analgesic effect of co-administrated ibuprofen and caffeine
Researchers showed that caffeine can be an effective analgesic adjuvant enhancing antinociceptive effect of ibuprofen in animals and humans and tablets containing well-soluble ib uprofen salt and caffeine could be easily prepared.


Perspectives in nonsteroidal anti-inflammatory agents.
  • T. Shen
  • Biology, Medicine
    Angewandte Chemie
  • 1972
Competitive binding and antagonistic interactions between nonsteroidal drugs, particularly salicylate, were observed in vitro and in vivo.
Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (—)‐isomer
The results indicate that the (+)-isomers of ibuprofen was highly active but that very little activity occurred in the (-)-isomer, and a large difference in potency was not found in vivo when they were compared simultaneously with the racemic substance in anti-inflammatory and analgesic tests.
Some Biological Properties of ‘Ibufenac’, a New Anti-rheumatic Drug
The properties of ‘Ibufenac’, which Chalmers and Duthie have recently shown to be effective in the treatment of rheumatoid arthritis, are described.
Clinical Safety of Flurbiprofen
Clinical safety data indicate that in the doses studied, flurbiprofen is a well tolerated agent for patients requiring nonsteroidal antiinflammatory drug therapy.
Some aspects of the pharmacology of ibufenac, a non‐steroidal anti‐inflammatory agent
Ibufenac, a compound chemically unrelated to existing antirheumatic drugs, can thus be classified as a non‐steroidal anti‐inflammatory (antirhematic) agent.
The metabolism of ibuprofen.
After oral administration ibuprofen appeared mainly in unchanged form in the plasma of rats, dogs, baboons and men, and was strongly bound to plasma protein in vitro, 95% being bound in baboon, 96% in rat, and 94% in dog plasma.
Stereoselective disposition of ibuprofen enantiomers in man.
It was found that formation of ester glucuronide conjugates stereoselectively favoured the S(+) enantiomer, and the kinetics of the individual enantiomers were altered by concurrent administration of the respective optical antipode.
Ibuprofen Overdose: The First Two Years of Over-the-Counter Sales
The London centre of the National Poisons Information Service began a new prospective survey of ibuprofen overdose at the time of OTC release, and found no evidence to contradict the former claims of low toxicity.
Ibuprofen overdose--a prospective study.
Of 61 cases of ibuprofen overdosage reported consecutively to the Rocky Mountain Poison and Drug Center from September 1985 through April 1986, 16 were excluded because of incomplete follow-up or