The Propionic Acids: A Personal Perspective

@article{Adams1992ThePA,
  title={The Propionic Acids: A Personal Perspective},
  author={S. S. Adams},
  journal={The Journal of Clinical Pharmacology},
  year={1992},
  volume={32}
}
  • S. Adams
  • Published 1 April 1992
  • Medicine
  • The Journal of Clinical Pharmacology
In searching during the early 1950s for new drugs for the treatment of rheumatoid arthritis, little information was available to allow a rational approach. The mode of action of the few drugs available was unknown and even the analgesic action of aspirin could not be demonstrated in animals. A speculative concept was developed that aspirin possessed a specific unidentified action in rheumatoid arthritis and that this and its analgesic properties were related to its ability to delay the… Expand
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63 Citations

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The formation energies of a series of substituted derivatives in - position of ibuprofen (2-p-isobutyl-phenyl-propionic acid) are determined, at the ab initio level RHF/6-311G** with full geometry… Expand
[A short history of anti-rheumatic therapy. III. Non steroidal anti-inflammatory drugs].
TLDR
Progress derived from the discovery of the mechanism of action of these drugs: the inhibition of synthesis of prostaglandins due to the cycloxigenase enzyme system, according to the experimental contributions of John R. Vane. Expand
Choosing the Right Nonsteroidal Anti-Inflammatory Drug for the Right Patient
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The major differences between NSAIDs are their therapeutic half-lives and safety profiles, and individual patient-specific and NSAID-specific pharmacokinetic principles should be considered. Expand
Acyl glucuronides: the good, the bad and the ugly.
TLDR
A review of the intrinsic reactivity, metabolic stability and pharmacokinetic properties of acyl glucuronides in the context of physiological, pharmacological and toxicological perspectives concluded that these might be attenuated substantially in vivo by rapid clearance of the conjugates. Expand
Influence of piperine on ibuprofen induced antinociception and its pharmacokinetics.
TLDR
Piperine (10 mg/kg) significantly increased the dose-dependent antinociceptive activity of ibuprofen evaluated by both acetic acid writhing and formalin test, when it was administered with ib uprofen. Expand
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