The Promise of Plant-Derived Substances as Inhibitors of Arginase.

@article{GirardThernier2015ThePO,
  title={The Promise of Plant-Derived Substances as Inhibitors of Arginase.},
  author={Corine Girard-Thernier and T-N Pham and C{\'e}line Demougeot},
  journal={Mini reviews in medicinal chemistry},
  year={2015},
  volume={15 10},
  pages={798-808}
}
The enzyme arginase catalyses the divalent cation dependent hydrolysis of L-arginine to produce L-ornithine and urea. Two isoforms of arginases have been identified in mammalian (including human) cells. Moreover, some infectious pathogens (e.g. Leishmania) synthesize their own arginase. Work over the last decades has revealed that elevated arginase activity… CONTINUE READING